Women, Pregnancy, and Substance Use

Enrichment Materials for Researchers and Clinical Scholars

📚 Extended Literature Review

The MOTHER Study

Jones HE, et al. Neonatal Abstinence Syndrome after Methadone or Buprenorphine Exposure. N Engl J Med. 2010.

Landmark RCT demonstrating buprenorphine results in less severe NOWS than methadone. Both are safe and effective for pregnant women with OUD.

Postpartum Overdose Prevention

Schiff DM, et al. Fatal and non-fatal overdose among pregnant and postpartum women in Massachusetts. Obstet Gynecol. 2018.

Demonstrated overdose risk peaks 7-12 months postpartum. Informed the AIM Patient Safety Bundle.

Eat-Sleep-Console Protocol

Grossman MR, et al. An initiative to improve the quality of care of infants with neonatal abstinence syndrome. Pediatrics. 2017.

Demonstrated ~50% reduction in pharmacologic treatment with ESC approach compared to Finnegan-based care.

Contingency Management for Stimulants

Preston KL, et al. Contingency management for stimulant use disorders: A systematic review. J Addict Med. 2020.

Confirmed CM as strongest evidence-based treatment for stimulant use disorder in pregnancy.

🎓 Teaching Resources

Longitudinal Cases

Three comprehensive cases (Maria/Keisha/Sarah) spanning ED → OB → Postpartum with teaching points.

Board Question Bank

15 ABPN-style questions with detailed rationales covering all major topics.

Implementation Toolkit

Workflows for warm handoffs, POSC templates, and ESC protocol implementation.

Patient Education Materials

Handouts on MOUD in pregnancy, NOWS, breastfeeding on MOUD, and postpartum safety.

🔗 Related Topics