Enrichment Materials for Researchers, Advanced Learners, and Clinical Scholars
Greenfield SF, et al. Sex and gender effects in recovery from alcohol use disorder. Drug Alcohol Depend. 2020.
Demonstrated naltrexone efficacy in women when adequately powered. Early underpowered trials created false impression of reduced efficacy in women.
Morley KC, et al. Sex as a potential moderator for baclofen response. Alcohol Clin Exp Res. 2022.
Secondary analysis of BacALD trial showing women had significant lapse delay (OR 7.74) while men did not. Estrogen-GABA-B receptor interaction proposed mechanism.
Quintrell EB, et al. The Safety of Alcohol Pharmacotherapies in Pregnancy. CNS Drugs. 2024.
Scoping review of 105 studies. Only 3.8% examined AUD medications in pregnancy context. Concluded naltrexone could be considered when psychosocial treatment fails.
Hernandez-Diaz S, et al. Topiramate and oral clefts. Neurology. 2018.
Large case-control study demonstrating 3.3× increased risk of oral clefts with first-trimester topiramate exposure. Dose-dependent relationship observed.
Interactive tool for naltrexone titration schedules based on patient factors.
Documentation template for verifying LARC before topiramate prescribing.
Detailed counseling scripts for reproductive-life-cycle conversations.
Detailed protocol for proposed sex-stratified AUD pharmacotherapy trial.