Complex Psychopharmacology Case Review

Patient: Ashwini Srinivasamohan (35F) | DOB: 08/27/1990

Visit Date: March 5, 2026

Reviewer: Psychiatric MD Collaborator

Review Date: March 19, 2026

Collaborating Provider: Stacy Pascarella, APRN

Overall Assessment: Reasonable Course with Enhancements

The clinical decision-making demonstrates comprehensive medication management, appropriate risk mitigation, and strong patient-centered care. The current course is reasonable and approvable with specific recommendations to optimize outcomes.

Diagnostic Formulation

DiagnosisCodeStatusRecommendation
Bipolar II Disorder, Current Episode Depressed, Moderate F31.32 ✅ Appropriate Maintain; mood stability confirmed; no hypomanic symptoms
ADHD, Unspecified Type F90.9 ✅ Appropriate Maintain; partial response; formulation change indicated
Generalized Anxiety Disorder F41.1 ✅ Appropriate GAD-7 score of 11 supports moderate anxiety
Alcohol Dependence, In Remission F10.21 ✅ Appropriate Naltrexone-supported; 2 drinking episodes since last visit
Binge Eating Disorder, Unspecified F50.819 ⚠️ Consider formal assessment PHQ-9 Item 5 score 3; consider BES (Binge Eating Scale)
Drug-Induced Subacute Dyskinesia G24.01 ✅ Appropriate Geodon-induced; AIMS score 7 (minimal); stable
Additional consideration: Nightmare Disorder (F51.5) — persistent despite prazosin; warrants separate specification and targeted intervention.

Psychopharmacology Review

Current Medications

MedicationDoseAssessmentRecommendation
Venlafaxine XR 187.5mg daily Reasonable with caution SNRI in bipolar disorder requires mood stabilizer coverage. Monitor for mood elevation.
Lamotrigine 100mg daily ⚠️ Subtherapeutic Target 200mg for acute bipolar depression. Consider titration to 150-200mg.
Adderall IR → XR 30mg daily Appropriate IR with afternoon crash indicates inadequate duration. XR conversion approved.
Naltrexone 50mg daily Appropriate Effective for alcohol craving; continue with mandatory LFT monitoring.
Prazosin 2mg nightly ⚠️ Questionable efficacy Nightmares persist; consider discontinuation trial or dose optimization.
Doxepin 10mg nightly Appropriate Low-dose TCA for sleep maintenance; minimal anticholinergic effects.
Gabapentin 300mg PRN Appropriate Anxiolytic use; monitor for tolerance and misuse potential.
Propranolol 20mg BID PRN Appropriate Performance/situational anxiety; monitor for hypotension.

Critical Monitoring Protocols

1. Tardive Dyskinesia Monitoring

2. Liver Function Monitoring (Naltrexone)

3. Mood Stability Monitoring (Venlafaxine + Bipolar II)

Priority Clinical Recommendations

🔴 HIGH PRIORITY: Lamotrigine Optimization

Rationale: Current 100mg is subtherapeutic for acute bipolar depression. Evidence supports 200mg as target dose.

Action: Titration schedule: 100mg × 2 weeks → 150mg × 2 weeks → 200mg maintenance. Monitor for rash.

🟡 MEDIUM PRIORITY: Stimulant Formulation Change

Rationale: Afternoon crash on IR indicates inadequate duration. XR provides smoother coverage.

Action: Convert Adderall IR 30mg to XR 30mg morning. Monitor for sleep disruption.

🟡 MEDIUM PRIORITY: Prazosin Efficacy Reassessment

Rationale: Nightmares persist despite 2mg nightly. Uncertain benefit after adequate trial.

Action: Consider 4-week discontinuation trial with nightmare diary. Evaluate for PTSD features if nightmares persist off medication.

Risk Stratification Summary

Risk DomainLevelMitigation Strategy
Antidepressant-induced mania (venlafaxine)ModerateLamotrigine coverage; close mood monitoring
Liver toxicity (naltrexone)ModerateScheduled LFT monitoring; patient education
Tardive dyskinesia progressionLowQuarterly AIMS; stable current score
Stimulant misuse/diversionLowXR formulation reduces abuse potential
Alcohol relapseModerateNaltrexone adherence; counseling support